GHK-Cu 50mg

Description

GHK-Cu 50mg | Copper Peptide Complex | Glycyl-L-Histidyl-L-Lysine Copper(II)

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper(II)) is a naturally occurring human plasma tripeptide-copper complex first isolated and characterized by Dr. Loren Pickart in 1973. Composed of the tripeptide GHK (Gly-His-Lys) coordinated with a divalent copper ion (Cu²⁺), GHK-Cu represents one of the most extensively studied and published copper-peptide complexes in the scientific literature, with a research bibliography spanning over five decades across a remarkably broad range of molecular biology, biochemistry, and cellular research disciplines.

As an endogenously occurring compound naturally present in human plasma, saliva, and urine — with documented plasma concentrations declining measurably with advancing age in research models — GHK-Cu has attracted sustained investigative interest as a tool compound for studying copper ion transport and bioavailability, extracellular matrix protein expression, and metallopeptide coordination chemistry in controlled laboratory settings. Its high-affinity copper(II) binding, mediated principally through the imidazole nitrogen of the histidine residue, has made it a reference compound of particular interest in bioinorganic chemistry and copper chaperone research.

GHK-Cu has accumulated an exceptionally broad peer-reviewed literature base encompassing investigations into its interactions with over 30 copper-dependent enzymes, its documented effects on superoxide dismutase (SOD) activity in cell culture models, its role in extracellular matrix remodeling research involving collagen, elastin, and glycosaminoglycan synthesis pathways, and its well-characterized antioxidant activity profiles in oxidative stress research models. The compound’s documented ability to modulate a wide array of genes involved in tissue remodeling, antioxidant defense, and anti-inflammatory signaling cascades — as reported across numerous peer-reviewed publications — has established it as one of the most versatile and widely referenced metallopeptide tool compounds available for investigative research.

Santa Cruz Peptides’ GHK-Cu 50mg is supplied as a lyophilized powder under inert atmosphere, independently verified for identity, purity, copper coordination integrity, and molecular weight via HPLC, ICP-MS, and mass spectrometry. A full certificate of analysis is included with every batch.

Intended strictly for research purposes. Not for human or veterinary use. Not for consumption. For laboratory and investigative use only.

Specifications