Description
Semax 10mg | Synthetic Heptapeptide | ACTH(4-7) Analog
Semax is a synthetic heptapeptide analog derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH), specifically the ACTH(4-7) core sequence (Met-Glu-His-Phe), extended with a Pro-Gly-Pro C-terminal tripeptide to confer enhanced enzymatic stability and prolonged research utility relative to the native ACTH fragment. Originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax has been the subject of an extensive and growing body of peer-reviewed literature spanning several decades, establishing it as one of the most thoroughly investigated synthetic neuropeptide analogs in academic research.
Structurally, Semax’s derivation from the melanocortin family of peptides positions it as a valuable tool compound for researchers investigating ACTH receptor fragment pharmacology, melanocortin system signaling, and structure-activity relationships within the ACTH peptide family. The C-terminal Pro-Gly-Pro extension, shared with the closely related compound Selank, is a well-documented peptide stabilization strategy that has been of independent research interest in studies examining enzymatic resistance mechanisms and neuropeptide half-life modulation.
Semax has accumulated a particularly concentrated body of published research examining its interactions with brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression models, serotonergic and dopaminergic signaling pathways, and nitric oxide synthase activity in controlled in vitro and in vivo laboratory settings, making it a widely referenced compound across neuroscience, molecular biology, and neuropeptide pharmacology research disciplines.
Santa Cruz Peptides’ Semax 10mg is supplied as a lyophilized powder under inert atmosphere, independently verified for sequence integrity, purity, and molecular weight via HPLC and mass spectrometry. A full certificate of analysis is included with every batch.
Intended strictly for research purposes. Not for human or veterinary use. Not for consumption. For laboratory and investigative use only.
Specifications
| Property | Detail |
|---|---|
| Compound | Semax |
| Class | Synthetic Heptapeptide / ACTH(4-7) Analog |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Form | Lyophilized powder |
| Quantity | 10mg |
| Purity | ≥99% |
| Molecular Formula | C₃₅H₄₈N₈O₁₀S |
| Molecular Weight | 780.87 g/mol |
| CAS Number | 80714-61-0 |
| Storage | −20°C, protect from light and moisture |
| Analysis | HPLC, Mass Spectrometry |
| Certificate of Analysis | Included with every batch |





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