Description
MOTS-c 10mg | Mitochondrial-Derived Peptide
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome, specifically derived from the 12S ribosomal RNA gene. As one of a small and growing class of endogenously encoded mitochondrial-derived peptides (MDPs), MOTS-c has emerged as a compelling subject of investigation in mitochondrial biology, retrograde signaling research, and intracellular metabolic pathway studies.
Unlike the vast majority of bioactive peptides, which are encoded by the nuclear genome, MOTS-c is notable for its mitochondrial origin, positioning it as a unique molecular tool for researchers exploring the intersection of mitochondrial function, nuclear gene regulation, and cellular energy metabolism. Its documented translocation from the mitochondria to the nucleus under specific experimental conditions has made it a subject of significant interest in mitochondria-to-nucleus retrograde communication research and AMPK pathway investigations.
MOTS-c has been the subject of peer-reviewed studies across a range of research disciplines, making it an increasingly sought-after reference compound for laboratories investigating mitochondrial peptide biology, metabolic signaling networks, and age-associated cellular research models.
Santa Cruz Peptides’ MOTS-c 10mg is supplied as a lyophilized powder under inert atmosphere, independently verified for sequence integrity, purity, and molecular weight via HPLC and mass spectrometry. A full certificate of analysis is included with every batch.
Intended strictly for research purposes. Not for human or veterinary use. Not for consumption. For laboratory and investigative use only.
Specifications
| Property | Detail |
|---|---|
| Compound | MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) |
| Class | Mitochondrial-Derived Peptide (MDP) |
| Sequence | Tyr-Arg-Trp-Leu-Met-Thr-Leu-Leu-Tyr-Leu-Thr-Asn-Asp-Leu-Pro-Asn-NH₂ |
| Form | Lyophilized powder |
| Quantity | 10mg |
| Purity | ≥99% |
| Molecular Formula | C₁₀₁H₁₅₉N₂₅O₂₈S |
| Molecular Weight | 2174.57 g/mol |
| CAS Number | 1627580-64-6 |
| Storage | −20°C, protect from light and moisture |
| Analysis | HPLC, Mass Spectrometry |
| Certificate of Analysis | Included with every batch |





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